Overview |
| Pharmacogenomics (PGx) utilizes an individual's genetic profile to predict drug responses allowing for personalized drug and dosage selection, thereby enhancing the safety and efficacy of treatments. QPHI is leading the QPGx-CARES (Qatar Pharmacogenetics Clinical Applications and Research Enhancement Strategies) initiative, which aims to promote the advancement of pharmacogenomics in healthcare by standardizing its application across diverse healthcare settings. The strategic focus of QPGx-CARES is on the clinical integration of PGx to address existing research gaps and tackle challenges related to PGx application in routine healthcare in Qatar. The QPGx-CARES initiative serves as a comprehensive plan and framework for the nationwide implementation of PGx services. |
QPGx-CARES key elements for advancing pharmacogenetic research and clinical implementation in Qatar |
| QGPx-CARES plans to provide PGx-guided therapy for the most common diseases in Qatar with substantial morbidity and cost burdens, including cardiovascular, cancer, and mental health medication. We are implementing PGx in clinical practice through two approaches: reactive and preemptive. The reactive approach is initiated when high-risk medications are prescribed, or adverse drug reactions occur. While the preemptive approach aims to provide a comprehensive profiling of an individual's potential drug response, independent of the immediacy of medication needs. |
Current status and future approach |
| As part of the QPGx-CARES initiative for PGx implementation, we prioritize launching pilot projects focused on cardiovascular medicine as a key step toward broader, systemic integration of PGx services. This includes expanding elements such as genotyping processes and clinical decision support tools for PGx-guided prescribing. Our current implementation projects lay the groundwork for personalizing medications based on genetic profiles, addressing barriers in real-world settings from the perspectives of all key stakeholders. The anticipated outcomes of the QPGx-CARES initiative will provide valuable insights into how PGx data can be effectively used to personalize treatments and improve patient outcomes. |
